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However, with sophisticated medications like glucagon-like peptide-1 (GLP-1) receptor agonists, the cold acts as a destructive force rather than a preservative

Another study found that patients with type 2 diabetes and kidney disease who were prescribed GLP-1s had a 39% higher risk of requiring kidney replacement therapy (dialysis or transplant), compared to patients taking SGLT2 inhibitors

This unique administration requirement is necessary due to semaglutide's poor oral bioavailability, which is enhanced through co-formulation with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC)